Stress is inevitable—but the way you handle it is flexible.
By Elizabeth Adrian, RDN, CDN
• Sep 22, 2025
In our fast-paced world, stress has become so normalized it often goes unnoticed—until our bodies start sending signals we can’t ignore. From sleepless nights and racing thoughts to chronic fatigue and irritability, these symptoms aren’t signs of weakness. They’re signs of a nervous system stuck in survival mode.
At Sakara, we believe that beauty and well-being start from within—and that includes your inner ability to endure life’s stressors with grace. This article explores how chronic stress impacts your biology and offers ritual-based tools to help restore balance and build long-term emotional resilience.
The Biology of Burnout: What Stress Does to the Body
Stress, in short bursts, is adaptive. It primes you to meet a challenge—speeding up your heartbeat, sharpening your focus, and sending energy to your muscles and body. This is your hypothalamic-pituitary-adrenal (HPA) axis in action: a powerful cascade that floods your system with cortisol and adrenaline. (1) But what happens when the alarm never turns off?
When stress becomes chronic, this once-helpful response can become disruptive, affecting nearly every system in the body. Your body is built to sprint from a threat, but it’s not designed to live in that sprint.
Here’s how chronic stress can reshape your inner landscape:
- Hormone imbalance: Constant cortisol output can interfere with sex hormones, menstrual cycles, and thyroid function. (2)
- Digestive disturbance: Chronic stress has the potential to impair gastrointestinal function, alter gut microbiota, and increase intestinal permeability. (3)
- Sleep disruption: Dysregulated cortisol rhythms make it harder to fall (and stay) asleep. (4)
- Immune suppression: Long-term stress reduces immune system efficiency, increasing susceptibility to illness. (5)
Cognitive fog: Chronic stress impairs prefrontal cortex function (focus, planning, regulation) and enlarges the amygdala (threat detection), increasing anxiety and reactivity. (6)
Your Nervous System: The Real Stress Command Center
Think of your nervous system as your body’s operating system. It regulates your heartbeat, breathing, digestion, hormones, and immune responses. During moments of stress, it prioritizes survival—activating the sympathetic nervous system (aka “fight or flight”) while dialing down long-term processes like regeneration and creativity.
The good news? Your nervous system is plastic, meaning it can learn, recover, and adapt over time. When it’s supported consistently, your body becomes more resilient. You start to think more clearly, and sleep more deeply. And instead of reacting, you respond with intention.
The Long-Term Effects of Chronic Stress
When left unregulated, chronic stress doesn’t just drain your energy. It can increase the risk for serious health conditions and accelerate biological aging.
Research links chronic stress to:
- Cardiovascular disease (7)
- Blood sugar dysregulation and insulin resistance (8)
- Anxiety and depression (9)
- Weakened immune function (10)
- Cognitive decline (11)
- Gut disorders, including irritable bowel syndrome (IBS) (3)
- Shortened telomeres, a cellular marker of accelerated aging (12)
Even before illness sets in, the toll is often emotional: burnout, disconnection, and an overall feeling of depletion.
How to Overcome Burnout and Rebuild Resilience
Recovery isn’t about removing stress entirely. It’s about giving yourself consistent opportunities to return to a state of balance. Here’s how:
1. Nourish Your Stress Response System
Just like your muscles, your stress response system requires the right fuel to stay strong and flexible.
- Magnesium-rich foods like leafy greens, nuts and seeds, legumes, and whole grains help regulate cortisol and support neurotransmitter balance. (13)
- Omega-3 fatty acids from flax, chia, and walnuts help reduce inflammation and buffer against mood imbalances. (18)
- Stable blood sugar is a critical component–aim for meals rich in fiber, healthy fats, and plant-based protein to avoid cortisol spikes.
Hydration and minerals (sodium, potassium, magnesium) support the body’s electrical signaling and stress response systems. (19)
2. Embrace the Parasympathetic
This is your “rest and digest” mode—the counterbalance to fight-or-flight. Simple, consistent practices help tone the vagus nerve (your nervous system’s brake pedal):
- Deep belly breathing
- Gentle movement like yoga or walking
- Cold exposure or splashing cold water on your face
- Singing or humming
- Taking 60 seconds to pause before a task
3. Restore Your Rhythm
Your body craves predictability, especially when it comes to sleep.
- Get morning sunlight to reset your circadian clock
- Avoid caffeine after noon and screentime before bed
- Wind down with non-stimulating rituals, such as herbal tea, a warm bath, journaling
A well-regulated sleep-wake cycle helps cortisol and melatonin stay in sync, improving your energy, mood, and ability to handle stress. (4)
4. Supplement Smartly (When Needed)
While lifestyle is foundational, there are some tools that can offer fast-acting support when stress is at its peak.
Serene State was designed for just that—a clinically-backed, plant-based supplement formulated to help promote calmness, focus, and emotional resilience.
Its key ingredients include:
- ZembrinⓇ, a standardized extract of kanna (Sceletium tortuosum), shown in clinical studies to promote calm, enhance executive function, and support a healthy stress response. (15-16)
L-theanine, a naturally occurring amino acid found in tea, has shown to promote relaxation and improve attention under stress. (17)
Resilience is a Ritual
Burnout doesn’t mean you’re broken, it means your body has been doing its best to survive without enough support.
Emotional resilience isn’t a personality trait–it’s a physiological skill. And like any skill, it’s built through practice: nourishment, rest, breath, movement, and ritual. Let this be your invitation to start small.
References
- McEwen BS. Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol Rev. 2007;87(3):873-904. https://pubmed.ncbi.nlm.nih.gov/17615391/
- Chrousos GP. Stress and disorders of the stress system. Nat Rev Endocrinol. 2009;5(7):374-381. https://pubmed.ncbi.nlm.nih.gov/19488073/
- Moloney RD, Desbonnet L, Clarke G, Dinan TG, Cryan JF. The microbiome: stress, health and disease. Mamm Genome. 2014;27)7-8):113-124. https://pubmed.ncbi.nlm.nih.gov/24281320/
- Meerlo P, Sgoifo A, Suchecki D. Restricted and disrupted sleep: effects on autonomic function, neuroendocrine stress systems and stress responsivity. Sleep Med Rev. 2008;12(3):197-210. https://pubmed.ncbi.nlm.nih.gov/18222099/
- Glaser R, Kiecolt-Glaser JK. Stress-induced immune dysfunction: implications for health. Nat Rev Immunol. 2005;5(3):243-251. https://pubmed.ncbi.nlm.nih.gov/15738954/
- Arnsten AF. Stress signalling pathways that impair prefrontal cortex structure and function. Nat Rev Neurosci. 2009;10(6):410-422. https://pubmed.ncbi.nlm.nih.gov/19455173/
- Steptoe A, Kivimäki M. Stress and cardiovascular disease. Nat Rev Cardiol. 2012;9(6):360-370. https://pubmed.ncbi.nlm.nih.gov/22473079/
- Black PH. The inflammatory response is an integral part of the stress response: Implications for atherosclerosis, insulin resistance, type II diabetes and metabolic syndrome X. Brain Behav Immun. 2003;17(5):350-364. https://pubmed.ncbi.nlm.nih.gov/12946657/
- Hammen C. Stress and depression. Annu Rev Clin Psychol. 2005;1:293-319. https://pubmed.ncbi.nlm.nih.gov/17716090/
- Segerstom SC, Miller GE. Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychol Bull. 2004;130(4):601-630. https://pubmed.ncbi.nlm.nih.gov/15250815/
- Liston C, McEwen BS, Casey BJ. Psychosocial stress reversibly disrupts prefrontal processing and attentional control. Procl Natl Acad Sci USA. 2009;106(3):912-917. https://pubmed.ncbi.nlm.nih.gov/19139412/
- Epel ES, Blackburn EH, Lin J, et al. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci. 2004:101(49):17312-17315. https://pubmed.ncbi.nlm.nih.gov/15574496/
- Pickering G, Mazur A, Trousselard M, et al. Magnesium status and stress: the vicious circle concept revisited. Nutrients. 2020;12(12):3672. https://pubmed.ncbi.nlm.nih.gov/33260549/
- Boyle NB, Lawton C, Dye L. The effects of magnesium supplementation on subjective anxiety and stress-a systematic review. 2017;9(5):429. https://pubmed.ncbi.nlm.nih.gov/28445426/
- Terburg D, Syal S, Rosenberger LA, et al. Acute effects of Sceletium tortuosum (Zembrin), a dual 5-HT reuptake and PDE4 inhibitor, in the human amygdala and its connection to the hypothalamus. Neuropsychopharmacology. 2013;38(13):2708-2716. https://pubmed.ncbi.nlm.nih.gov/23903032/
- Chiu S, Gericke N, Farina-Woodbury M, Badmaev V, et al. (2014). Proof-of-Concept Randomized Controlled Study of Cognition Effects of the Proprietary Extract Sceletium tortuosum (Zembrin) Targeting Phosphodiesterase-4 in Cognitively Healthy Subjects: Implications for Alzheimer’s Dementia. Evid Based Complement Alternat Med. 2014;2014:682014. https://pubmed.ncbi.nlm.nih.gov/25389443/
- Nobre, AC, Rao A, & Owen GN. L-theanine, a natural constituent in tea, and its effects on mental state. Asia Pac J Clin Nutr. 2008;17(S1):167-168. https://pubmed.ncbi.nlm.nih.gov/18296328/
- Grosso G, Galvano F, Marventano S, et al. Omega-3 fatty acids and depression: scientific evidence and biological mechanisms. Oxid Med Cell Longev. 2014:313570. https://pubmed.ncbi.nlm.nih.gov/24757497/
- Smith JA, Pati D, Wang L, et al. Hydration and beyond: neuropeptides as mediators of hydromineral balance, anxiety and stress-responsiveness. Fron Syst Neurosci. 2015:9.46. https://pubmed.ncbi.nlm.nih.gov/25873866/